Process for the preparation of deuterated ethanol from d2

ABSTRACT

The invention relates to a process for the preparation of a deuterated ethanol from an acetic acid, an acetate, or an amide by reaction with D2 in the presence of a transition metal catalyst.

FIELD OF THE INVENTION

The present invention relates to a process for the preparation of a deuterated ethanol from D₂.

BACKGROUND OF THE INVENTION

Deuterium (D or ²H) is a stable, non-radioactive isotope of hydrogen. Deuterium-enriched organic compounds such as a deuterated ethanol are known. U.S. Pat. No. 8,658,236 describes an alcoholic beverage of water and ethanol, wherein at least 5 mole percent of the ethanol is a deuterated ethanol. This alcoholic beverage is believed to diminish the negative side effects associated with the consumption of ethanol.

The production of a deuterated-ethanol containing alcoholic beverage requires the preparation of a deuterated ethanol in an efficient, safe, and cost-effective manner. A known process for the preparation of a deuterated alcohol (e.g., deuterated ethanol) involves an H/D exchange reaction between a non-deuterated alcohol and D₂O. Depending on the process, the resulting deuterated alcohol may comprise deuterium in different positions. Examples of such processes can be found in Chemistry Letters 34, No. 2 (2005), p. 192-193 “Ruthenium catalyzed deuterium labelling of α-carbon in primary alcohol and primary/secondary amine in D₂O”; Adv. Synth. Catal. 2008, 350, p. 2215-2218 “A method for the regioselective deuteration of alcohols”; Org. Lett. 2015, 17, p. 4794-4797 “Ruthenium Catalyzed Selective α- and α,β-Deuteration of Alcohols Using D₂O” and Catalysis Communications 84 (2016) p. 67-70 “Efficient deuterium labelling of alcohols in deuterated water catalyzed by ruthenium pincer complexes”.

Other routes to produce a deuterated alcohol involve several consecutive reactions requiring expensive and/or hazardous material. For each of these transformations, purification and isolation of the intermediates are necessary.

In view of the above, it is desirable to be able to synthesize deuterated ethanol in an efficient, safe and cost-effective manner It is further desirable to synthesize deuterated ethanol with deuteration substantially only at a desired position(s).

SUMMARY OF THE INVENTION

In an aspect, the present invention provides a process for the preparation of deuterated ethanol from ethanol, D₂, and a catalyst.

These and other aspects, which will become apparent during the following detailed, have achieved by the inventors' discovery of a new process of making deuterated ethanol.

DETAILED DESCRIPTION OF THE INVENTION

Thus, in an aspect, the present invention provides a novel process for the preparation of a deuterated ethanol of formula (I):

CR¹R²R³CR⁴R⁵OH  (I)

comprising: reacting compound (II) with D₂ in the presence of a catalyst of formula (III):

ML_(a)X_(b)  (III)

wherein:

R¹-R⁵ are independently H or D, provided that the abundance of D in R⁴ and R⁵ is at least 70%;

compound (II) is selected from: acetic acid, an acetate, and an amide;

M is a transition metal;

L is a ligand;

X is a counterion;

a is an integer selected from 1-5; and,

b is an integer selected from 0-5.

The abundance of D in R⁴ and R⁵ (the CH₂ position) and in R¹, R², and R³ (the CH₃ position) can be measured by ¹H NMR. The 70% abundance of D in R⁴ and R⁵ means that 70% of all R⁴ and R⁵ present are D (as opposed to the natural abundance of 0.01%).

The process of the present invention uses D₂ as the deuterium source which is a non-toxic gas. The amount of the catalyst (III) required for the process is very small, making the process cost effective. Also, the catalyst (III) can be easily separated from the desired product.

In another aspect, the abundance of D in R⁴ and R⁵ is at least 80%. Additional examples of the abundance of D in R⁴ and R⁵ include at least 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, and 99.5%.

In another aspect, the incorporation of D occurs preferentially in R⁴ and R⁵ over R¹-R³. In another aspect, the abundance of D in R¹-R³ is at most 50%. Additional examples of the abundance of D in R¹-R³ include at most 45, 40, 35, 30, 25, 20, 15, 10, 5, and 1%.

In another aspect, the abundance of D in R⁴ and R⁵ is at least 90% and the abundance of D in R¹-R³ is at most 5%. Additional examples include (a) at least 95% and at most 1%, and (b) at least 99% and at most 1%.

The conversion of ethanol to deuterated ethanol in the present process can be determined by ¹H NMR. The conversion is the molar ratio of deuterated ethanol formed divided by the initial amount of starting ethanol (un-enriched ethanol). In an aspect, the conversion percentage (molar ratio×100) is at least 90%. Additional examples of the conversion percentage include at least 95%, at least 98%, and at least 99%.

As noted above, compound (II) is selected from acetic acid, an acetate, and an amide.

In another aspect, compound (II) is acetic acid, which is a compound having the formula CH₃COOH (or CH₃CO₂H).

In another aspect, compound (II) is an acetate of formula (IIA):

CH₃COOR⁶  (IIA)

wherein:

R⁶ is selected from: a C₁ or C₃₋₁₀ alkyl group, a C₁₋₁₀ substituted alkyl group, a C₆₋₁₈ aromatic ring group, a C₆₋₁₈ substituted aromatic ring group, and a glycol ether group;

alternatively, R⁶ is selected from: —R⁷—OCOCH₃ and —CH—(R⁸OCOCH₃)(R⁹OCOCH₃);

R⁷ is selected from: a C₁₋₁₀ alkylene group, a substituted C₁₋₁₀ alkylene group, a C₆₋₁₈ aromatic ring group, a C₆₋₁₈ substituted aromatic ring group, and a glycol ether group; and,

R⁸ and R⁹ are independently selected from: a C₁₋₁₀ alkylene group, a substituted C₁₋₁₀ alkylene group, a C₆₋₁₈ aromatic ring group, a C₆₋₁₈ substituted aromatic ring group, and a glycol ether group.

In another aspect, in the acetate represented by the formula CH₃COOR⁶, R⁶ has a structure such that an alcohol made from R⁶ represented by R⁶OH is a primary or a secondary alcohol. In other words, R⁶ is bonded to CH₃COO— by a carbon atom having at least one H (e.g., a —CH—, CH₂—, or —CH₃ moiety).

Examples of the acetate represented by the formula CH₃CO₂R⁶ include methyl acetate, n-propyl acetate, i-propyl acetate, n-butyl acetate, i-butyl acetate, di(propylene glycol) methyl ether acetate, and phenyl acetate.

Examples of the acetate represented by the formula CH₃CO₂R⁷OCOCH₃ include ethylene glycol diacetate (R⁷ is ethylene) and propylene glycol diacetate (R⁷ is i-propylene).

An example of the acetate represented by the formula CH₃CO₂CH(R⁸OCOCH₃)(R⁹OCOCH₃) is glyceryl triacetate (R⁸ and R⁹═CH₂).

In another aspect, compound (II) is an acetate selected from: methyl acetate, n-propyl acetate, i-propyl acetate, n-butyl acetate, i-butyl acetate, di(propylene glycol) methyl ether acetate, phenyl acetate, ethylene glycol diacetate, propylene glycol diacetate, and glyceryl triacetate.

In another aspect, compound (II) is an amide of formula (IIB):

CH₃CO—NR¹⁰R¹¹  (IIB)

wherein:

R¹⁰ and R¹¹ are independently selected from: H, a C₁₋₁₀ alkyl group, a C₁₋₁₀ substituted alkyl group, a C₆₋₁₈ aromatic ring group, and a C₆₋₁₈ substituted aromatic ring group;

alternatively, R¹⁰ and R¹¹ are linked to each other to form a 5-6 membered ring that optionally contains a hetero atom selected from: nitrogen, oxygen, and sulfur.

Examples of amides include CH₃CONH-phenyl (R¹⁰═H, R¹¹=phenyl), CH₃CONHCH₂CH₃ (R¹⁰═H, R¹¹=ethyl). Examples of NR¹⁰R¹¹ being a ring include morpholine and piperidine.

In another aspect, the glycol ether group of R⁶, R⁷, or R⁸ is selected from a compound of formula (IIC) and (IID):

—R¹²—O—R¹³  (IIC)

—R¹²—O—R¹⁴—O—R¹³  (IID)

wherein:

R¹² and R¹³ are independently selected from: a C₁₋₁₀ alkyl group; and,

R¹⁴ is a C₁₋₁₀ alkylene group.

In another aspect, R¹² and R¹³ are independently selected from: a C₁₋₆ alkyl group and R¹⁴ is a C₁₋₆ alkylene group.

In another aspect, R¹²═CH₃, R¹³═CH₃, and R¹⁴═—CH₂—.

The catalyst of formula (III) is suitable for the reduction of an ester or an amide to the corresponding alcohol or amine.

In another aspect, transition metal “M” is selected from: Fe, Co, Ni, Mn, Pd, Pt, Rh, Ru, Os and Ir.

In another aspect, the transition metal is selected from: Pd, Pt, Rh, Ru and Ir.

In another aspect, the transition metal is Ru.

Ligand “L” is any ligand suitable for the reduction of esters or amides. In another aspect, the ligand is selected from: a monodentate ligand and a polydentate ligand. Examples of monodentate ligands include phosphine (e.g., triphenylphosphine), carbon monoxide, an olefin, water, acetonitrile, dimethylsulfoxide. Examples of polydentate ligands include an olefin (e.g., cyclooctadiene), an amino phosphine (e.g., 2-(diphenylphosphanyl)ethan-1-amine and bis(2-(diphenylphosphanyl)ethyl)amine), a bypiridine (e.g., 4,4′-dimethoxy-2,2′-bipyridine).

When “a” is from 2 to 5, each of the ligands may be the same or different.

In another aspect, ligand L is carbon monoxide (CO).

In another aspect, counterion “X” is selected from: pentamethylcyclopentadienyl, chloride, bromide, iodide, hydride, triflate, and BH₄.

When “b” is from 2 to 5, each of the counterions may be the same or different.

In another aspect, one of the counterions X is hydride.

In another aspect, M, L, and X are as follows:

M is Ru;

L is selected from phosphine, carbon monoxide, olefin, water, acetonitrile, dimethylsulfoxide, amino phosphine, and bypiridine; and,

X is selected from pentamethylcyclopentadienyl, chloride, bromide, iodide, hydride, triflate, and BH₄.

In another aspect, the catalyst is a ruthenium complex of general formula (IV):

whererin:

each R¹⁵ is independently selected from: a hydrogen atom, a C₁₋₁₀ alkyl group, a substituted C₁₋₁₀ alkyl group, a C₆₋₁₈ aromatic ring group, and a substituted C₆₋₁₈ aromatic ring group;

each Ar is independently selected from a C₆₋₁₈ aromatic ring group and a substituted C₆₋₁₈ aromatic ring group; and,

each n is independently selected from an integer of 1 or 2.

The ruthenium catalysts of formula (IV) are known (see U.S. Pat. No. 8,003,838, US2013/0303774, and US2016/0039853, which are incorporated herein by reference).

In another aspect, the ligand L is a monodentate ligand.

In another aspect, L is selected from: phosphine (e.g., triphenylphosphine), carbon monoxide, olefin, water, acetonitrile and dimethylsulfoxide.

In another aspect, L is carbon monoxide.

In another aspect, X is selected from: pentamethylcyclopentadienyl, chloride, bromide, iodide, hydride, triflate, and BH₄.

In another aspect, one of X is hydride.

In another aspect, in formula (IV) two vicinal R¹⁵ (except hydrogen atoms) may form a cyclic structure by covalent bond of carbon atoms through or without a nitrogen atom, an oxygen atom or a sulfur atom.

In another aspect, in formula (IV), each Ar is phenyl.

In another aspect, n is 1 (each P is bound to the N in the Ru complex via a 2 carbon linker).

In another aspect, n is 2 (each P is bound to the N in the Ru complex via a 3 carbon linker).

In another aspect, n=1 and all R¹²=hydrogen.

In another aspect, L is carbon monoxide and one of X is hydride.

In another aspect, the catalyst is a Ru complex of formula (V) (which is commercially available as Ru-MACHO®)({Bis[2-(diphenylphosphino)ethyl]amine}carboynlchlorohydridoruthenium(II)):

wherein Ph=phenyl.

In another aspect, the catalyst is a Ru complex of formula (VI) (which is commercially available as Ru-MACHO®-BH)(Carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)amino]ruthenium(II)):

wherein Ph=phenyl.

In another aspect, the catalyst is a Ru complex of formula (VII) (Ru-Firmenich as described in Angew. Chem. Int. Ed. 2007, 46, 7473-7476);

wherein Ph=phenyl.

In another aspect, the catalyst is a Ru complex of formula (VIII) (Cp₃Ir(BiPy)(OTf)₂ as described in JACS, 2013, 135, 16022));

wherein Cp=cyclopentadienyl, BiPy=bipyridine, and OTf=triflate.

In another aspect, the catalyst is the compound of formula (VI) and the reaction is performed in the absence of a base. This results in a high selectivity for the D incorporation in R⁴-R⁵ over R¹-R³.

In another aspect, when the catalyst is the compound of formula (VI), then compound (II) is selected from: methyl acetate, n-propyl acetate, i-propyl acetate, n-butyl acetate, i-butyl acetate, and glyceryl triacetate.

In another aspect, the reaction is performed in the absence of base.

In another aspect, the reaction is performed in the presence of base.

Examples of the base include

-   -   a. alkali metal hydrogen carbonates (e.g., LiHCO₃, NaHCO₃, and         KHCO₃); alkali metal carbonates (e.g., Li₂CO₃, Na₂CO₃, and         K₂CO₃);     -   b. alkali metal hydroxides (e.g., LiOH, NaOH, and KOH);     -   c. tetraalkyl ammonium hydroxides (e.g., N(CH₃)₄OH,         N(CH₂CH₃)₄OH, N(CH₂CH₂CH₃)₄OH, and N(CH₂CH₂CH₂CH₃)₄OH,);     -   d. alkali metal alkoxides (e.g, LiOCH₃, NaOCH₃, KOCH₃,         LiOCH₂CH₃, NaOCH₂CH₃, KOCH₂CH₃, LiOCH(CH₃)₂, NaOCH(CH₃)₂,         KOCH(CH₃)₂, LiOC(CH₃)₄, NaOC(CH₃)₄, KOC(CH₃)₄;     -   e. organic bases (e.g., triethylamine, diisopropylethylamine,         4-dimethylaminopyridine, and         1,8-diazabicyclo[5.4.0]undec-7-ene);     -   f. alkali metal bis(trialkylsilyl)amides (e.g., lithium         bis(trialkylsilyl)amide, sodium bis(trialkylsilyl)amide, and         potassium bis(trialkylsilyl)amide); and     -   g. alkali metal borohydrides (e.g., LiBH₄, NaBH₄, and KBH₄).

In another aspect, the reaction is performed in the presence of an alkali metal alkoxide. Examples of alkali metal alkoxides include LiOCH₃, NaOCH₃, and KOCH₃.

In another aspect, the reaction is performed in the presence of an alkali metal borohydride. Examples of alkali metal borohydrides include LiBH₄, NaBH₄, and KBH₄.

In another aspect, the amount of the base is 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, to 10 mol % with respect to compound (II).

In another aspect, the catalyst is compound (V) (Ru-MACHO®) and the reaction is performed in the presence of a base. Examples of the base include NaBH₄ and KOCH₃. In another example, the base is NaBH₄. The combination of Ru-MACHO® and NaBH₄ results in a high selectivity for the D incorporation in R⁴-R⁵ over R¹-R³.

In another aspect, the catalyst is compound (VI) (Ru-MACHO®-BH) and the reaction is performed in the presence of a base.

In another aspect, the catalyst is compound (VI) (Ru-MACHO®-BH) and the reaction is performed in the absence of a base. This results in a high selectivity for the D incorporation in R⁴-R⁵ over R¹-R³.

In another aspect, the catalyst is compound (VII) (Ru-Firmenich) and the reaction is performed in the presence of a base. Examples of the base include KOCH₃ and NaBH₄. The use of KOCH₃ results in a higher conversion but low selectivity. The use of NaBH₄ results in a lower conversion but high selectivity.

In another aspect, the catalyst is compound (VIII) (Cp₃Ir(BiPy)(OTf)₂) and the reaction is performed in the presence of a base

In another aspect, the catalyst is compound (VIII) (Cp₃Ir(BiPy)(OTf)₂) and the reaction is performed in the absence of a base.

In another aspect, the reaction is performed under neat conditions without the use of a solvent.

In another aspect, the reaction is performed in the presence of an organic solvent.

Examples of the organic solvent include:

-   -   a. aliphatic hydrocarbon solvents (e.g., n-hexane and         n-heptane);     -   b. aromatic hydrocarbon solvents (e.g., toluene and xylene);     -   c. halogenated solvents (e.g., methylene chloride and         1,2-dichloroethane);     -   d. ether solvents (e.g., diethyl ether, 1,2-dimethoxyethane,         1,4-dioxane, tetrahydrofuran, 2-methyltetrahydrofuran,         tert-butyl methyl ether, diisopropyl ether, diethylene glycol         dimethyl ether, and anisole);     -   e. alcohol solvents (e.g., methanol, ethanol, n-propanol,         isopropanol, n-butanol, tert-butanol, n-pentanol, n-hexanol, and         cyclohexanol);     -   f. amide solvents (e.g., N,N-dimethylformamide and         1,3-dimethyl-2-imidazolidinone);     -   g. nitrile solvents (e.g., acetonitrile and propionitrile); and     -   h. dimethyl sulfoxide.

The organic solvents can be used solely or in combination of two or more thereof.

In another aspect, the solvent is selected from: tetrahydrofuran, methanol, and 1,4-dioxane.

The organic solvent may also be a deuterated organic solvent, i.e. an organic solvent listed above wherein at least one H is replaced by D. Examples include CD₃OD (perdeutero-methanol) and d₈-tetrahydrofuran (d₈-THF)(perdeutero-THF).

In another aspect, the amount of solvent is 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, to 10 L per mole of compound (II).

In another aspect, the reaction is performed with a D₂ pressure of 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, to 20 MPa. Examples of the pressure include from 1, 2, 3, 4 to SMPa of D₂.

In another aspect, the reaction temperature is at most 200° C. Examples of the reaction temperature include from 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 105, 110, 115, 120, to 125° C. Further examples include from 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 to 100° C. Other examples include from 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, to 90° C. (e.g., 70-90° C.).

In another aspect, the reaction is performed at a period of 0.5, 1, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 to 100 hours. Examples of the time the reaction is performed include from 1, 2, 4, 6, 8, 10, 12,14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70 to 72 hours.

In another aspect, compound (I) can be separated from the reaction product by any ordinary post treatment operation for organic synthesis. Further, the crude product can be purified to a high purity, as needed, by standard methods including, activated carbon treatment, fractional distillation, recrystallization, and column chromatography. It can be convenient to directly subject the completed reaction solution to a distillation recovery operation.

In the case where the reaction is performed in the presence of a base, the target compound of relatively high acidity tends to form a salt or complex with the base used and remain in the distillation residue during distillation recovery operation. In such a case, the target compound can be obtained with high yield by neutralizing the reaction completed solution with an organic acid (e.g., formic acid, acetic acid, citric acid, oxalic acid, benzoic acid, methanesulfonic acid or paratoluenesulfonic acid) or an inorganic acid (e.g., HCl, HBr, HNO₃, H₂SO₄) in advance, and then, subjecting the neutralized reaction completed solution to a distillation recovery operation (including recovery by washing the distillation residue with an organic solvent such as diisopropyl ether).

It is noted that the invention relates to all possible combinations of features described herein. It will therefore be appreciated that all combinations of features relating to the composition according to the invention; all combinations of features relating to the process according to the invention and all combinations of features relating to the composition according to the invention and features relating to the process according to the invention are described herein.

It should be understood that a description on a product/composition comprising certain components also discloses a product/composition consisting of these components. The product/composition consisting of these components may be advantageous in that it offers a simpler, more economical process for the preparation of the product/composition. Similarly, it should be understood that a description on a process comprising certain steps also discloses a process consisting of these steps. The process consisting of these steps may be advantageous in that it offers a simpler, more economical process.

Definitions

The examples provided in the definitions present in this application are non-inclusive unless otherwise stated. They include but are not limited to the recited examples.

When values are mentioned for a lower limit and an upper limit for a parameter, ranges made by the combinations of the values of the lower limit and the values of the upper limit are also understood to be disclosed.

“Alkyl” includes the specified number of carbon atoms in a linear, branched, and cyclic (when the alkyl group has 3 or more carbons) configuration. Alkyl includes a lower alkyl groups (C₁, C₂, C₃, C₄, C₅, and C₆ or 1-6 carbon atoms). Alkyl also includes higher alkyl groups (>C₆ or 7 or more carbon atoms).

When an “ene” terminates a group it indicates the group is attached to two other groups. For example, methylene refers to a —CH₂-moiety.

“Alkenyl” includes the specified number of hydrocarbon atoms in either straight or branched configuration with one or more unsaturated carbon-carbon bonds that may occur in any stable point along the chain, such as ethenyl and propenyl. C₂₋₆ alkenyl includes C₂, C₃, C₄, C₅, and C₆ alkenyl groups.

“Alkynyl” includes the specified number of hydrocarbon atoms in either straight or branched configuration with one or more triple carbon-carbon bonds that may occur in any stable point along the chain, such as ethynyl and propynyl. C₂₋₆ alkynyl includes C₂, C₃, C₄, C₅, and C₆ alkynyl groups.

“Substituted alkyl” is an alkyl group where one or more of the hydrogen atoms have been replaced with another chemical group (a substituent). Substituents include: halo, OH, OR (where R is a lower alkyl group), CF₃, OCF₃, NH₂, NHR (where R is a lower alkyl group), NR^(x)R^(y) (where R^(x) and R^(y) are independently lower alkyl groups), CO₂H, CO₂R (where R is a lower alkyl group), C(O)NH₂, C(O)NHR (where R is a lower alkyl group), C(O)NR^(x)R^(y) (where R^(x) and R^(y) are independently lower alkyl groups), CN, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₆₋₁₂ aromatic ring group, substituted C₆₋₁₂ aromatic ring group, 5-12 membered aromatic heterocyclic group, and substituted 5-12 membered aromatic heterocyclic group.

Examples of the aromatic ring group are aromatic hydrocarbon groups as typified by phenyl, naphthyl and anthryl.

Examples of the aromatic heterocyclic group are aromatic hydrocarbon groups containing hetero atoms e.g. as nitrogen, oxygen or sulfur as typified by pyrrolyl (including nitrogen-protected form), pyridyl, furyl, thienyl, indolyl (including nitrogen-protected form), quinolyl, benzofuryl and benzothienyl.

“Substituted aromatic ring group” or “substituted aromatic heterocyclic ring group” refers to an aromatic/aromatic heterocyclic ring group where at least one of the hydrogen atoms has been replaced with another chemical group. Examples of such other chemical groups include: halo, OH, OCH₃, CF₃, OCF₃, NH₂, NHR (where R is a lower alkyl group), NR^(x)R^(y) (where R^(x) and R^(y) are independently lower alkyl groups), CO₂H, CO₂R (where R is a lower alkyl group), C(O)NH₂, C(O)NHR (where R is a lower alkyl group), C(O)NR^(x)R^(y) (where R^(x) and R^(y) are independently lower alkyl groups), CN, lower alkyl, aryl, and heteroaryl.

“Halo” refers to Cl, F, Br, or I.

Other features of the invention will become apparent in the course of the following descriptions of exemplary embodiments that are given for illustration of the invention and are not intended to be limiting thereof.

EXAMPLES

The structures of the compound (II) tested are as follows:

The structures of the catalysts used are shown below.

Experiment Set 1

In a glovebox, under Na atmosphere, the catalyst (and base when required) was placed inside 5 mL vials under N₂ atmosphere. The solvent when used was added followed by the substrate (compound (II)). The vial was placed inside an autoclave and purged with D₂. The pressure of D₂ was increased to 50 bar and the temperature was increased to 70° C. while stirring at 500 rpm with a magnetic stirred. After 16 h, the reaction mixture was cooled. After purging with N₂, the autoclave was opened and the reaction mixture was analyzed by ¹H NMR to determine the conversion and D incorporation.

The reaction conditions were as follows: 50 bar D₂, Substrate=15-20 wt %, ratio of Substrate/Catalyst=1000, Base=5 mol % relative to substrate when present, 70° C., 16 h.

The experiments were performed using methyl acetate with various catalysts. Results are shown in Table 1.

TABLE 1 D inc. D inc. Catalyst Conv at CH₂ at CH₃ Exp Id mmol Substrate Solvent (%) (%) (%) 1 Ru-MACHO-BH 0.027 Me neat >99 >99 <1 Acetate 2 Ru-MACHO-BH 0.0027 Me d₈-THF >99 >99.2 <1 Acetate (1.4 mL) 3 Ru-MACHO-BH 0.0027 Me d₄-MeOH >99 99 3 Acetate (1.4 mL) 4 Ru-MACHO 0.0027 Me d₈-THF >99 95 68 Acetate (1.7 mL) 5 Ru-Firmenich 0.0027 Me d₈-THF >99 90 92 Acetate (1.7 mL) For experiments 4 and 5, KOMe (potassium methoxide) was added (50 eq/Ru).

The reaction of the acetate with D₂ results in a deuterated ethanol and a further (side-product) alcohol. The type of the further alcohol depends on the type of the acetate, e.g. when the acetate is methyl acetate, the further alcohol is methanol. The abundance of D in the CH₂ position and the CH₃ position was determined by subjecting the resulting mixture to ¹H NMR. The abundance of D in the CH₂ position was determined by the amount of the residual H in the CH₂ position. The “residual H at the CH₂ position” was determined by the normalized ratio of area of the CH₂ signal in the ethanol produced divided by the area of the signal of the further alcohol. The complement to 100 of this quantity equals to the abundance of D in the CH₂ position. The abundance of D in the CH₃ position was determined in a similar manner

In Exp 1, Ru-MACHO-BH gives full conversion of methyl acetate to a deuterated ethanol with a deuterium incorporation over 99% in the CH₂ position and no significant deuterium incorporation in the CH₃ position. The reaction was conducted without any solvent. Similar results were obtained when the reaction is done in THF or MeOH as solvent (Exp 2 and 3).

Ru-MACHO (Exp 4) or Ru-Firmenich (Exp 5) need to be activated by a strong base such as KOMe. In this case, a good conversion of Me acetate was observed but a significant D incorporation at CH₃ was also observed.

Exp 1 was repeated except that the pressure was 5 bar D₂ instead of 50 bar D₂. The conversion was 87% with 99% D incorporation at CH₂ position.

Experiment Set 2

The experiments were performed in the same way as in Experiment Set 1 using various substrates with Ru-MACHO-BH, except experiment 11 which uses Ru-MACHO. Results are shown in Table 2.

TABLE 2 D inc. D inc. Catalyst Conv at CH₂ at CH₃ Exp Id mmol Substrate Solvent (%) (%) (%) 6 Ru-Macho-BH 0.027 n-Pr Acetate neat >99 77 low if any 7 Ru-Macho-BH 0.027 n-Bu Acetate neat >99 77 low if any 8 Ru-Macho-BH 0.027 i-Pr Acetate neat 75 92 low if any 9 Ru-Macho-BH 0.027 i-Bu Acetate neat 100 77 low if any 10 Ru-Macho-BH 0.011 Glyceryl neat 67 99 triacetate 11 Ru-Macho 0.0017 tBu Acetate d₈-THF 32 n.d. n.d. (1.5 mL)

When Ru-Macho-BH was used as the catalyst, methyl acetate led to the highest selectivity for the D-incorporation at CH₂. The other acetates were also tested with Ru-Macho-BH without any solvent (Exp 6-10). Good conversions were obtained in all cases. However, a lower D incorporation at CH₂ position was obtained by the other acetates compared with methyl acetate (Exp 1). This may be due to H/D exchange between the alcohols formed. This H/D exchange may not occur in the case of MeOH produced when the acetate is methyl acetate.

Further, deuterated ethanol was obtained from tBu acetate using Ru-Macho as the catalyst although at a lower conversion (Ex 11).

Experiment Set 3

The experiments were performed in the same way as in Experiment set 1 using methyl acetate with various catalysts. Results are shown in Table 3.

The reaction conditions were as follows: neat, P(D₂)=50 bar, T=90° C., time=16 h.

TABLE 3 D inc. D inc. mmol tot V Conv at CH₂ at CH₃ Exp Catalyst Cat Subs. Mmol (mL) S:Cat (%) (%) (%) 12 Ru-Macho-BH 0.011 Me 13.8 1.1 1285 >99 97 low if any Acetate 13 Ru-Macho + NaBH₄ 0.0155 Me 6.3 0.5 406 >99 87 low if any (15 eq/Ru) Acetate 14 Ru-Firmenich + NaBH₄ 0.007 Me 6.3 0.5 900 36 >99 20 (7 eq/Ru) Acetate 15 Cp*Ir(BiPy)(OTf)₂ 0.023 Me 6.3 0.5 274 41 >99 22 Acetate

In Exp 13, the in-situ activation of Ru-Macho with NaBH₄ also gives an active catalyst leading to a good D incorporation. The selectivity towards D incorporation at the CH₂ position is higher than when KOMe is used as the base. The Firmenich catalyst activated in-situ with NaBH₄ led to an excellent D incorporation at CH₂ position but also with some D incorporation at CH₃ position. The conversion is lower than when KOMe is used as the base. In Exp 15, a catalyst based on Ir instead of Ru was also successful at producing the desired deuterated ethanol.

Numerous modifications and variations of the present invention are possible in light of the above teachings. It is therefore to be understood that within the scope of the appended claims, the invention may be practiced otherwise that as specifically described herein. 

1. A process for the preparation of a deuterated ethanol of the formula (I) CR¹R²R³CR⁴R⁵OD  (I) comprising: reacting compound (II) with D₂ in the presence of a catalyst of formula (IV):

wherein: R¹-R⁵ are independently H or D, provided that the abundance of D in R⁴ and R⁵ is at least 80% and the abundance of D in R¹-R³ is at most 50%; each R¹⁵ is independently selected from: a hydrogen atom, a C₁₋₁₀ alkyl group, a substituted C₁₋₁₀ alkyl group, a C₆₋₁₈ aromatic ring group, and a substituted C₆₋₁₈ aromatic ring group; each Ar is independently selected from a C₆₋₁₈ aromatic ring group and a substituted C₆₋₁₈ aromatic ring group; each n is independently selected from an integer of 1 or 2; compound (II) is an acetate; L is a ligand; and, X is a counterion.
 2. (canceled)
 3. The process of claim 1, wherein the process has a conversion to compound (I) of at least 90%.
 4. The process of claim 1, wherein compound (II) is an acetate selected from: methyl acetate, n-propyl acetate, i-propyl acetate, n-butyl acetate, i-butyl acetate, di(propylene glycol) methyl ether acetate, phenyl acetate, ethylene glycol diacetate, propylene glycol diacetate, and glyceryl triacetate.
 5. The process of claim 1, wherein compound (II) is an acetate represented by the formula CH₃COOR⁶, wherein an alcohol made from R⁶ represented by R⁶OH is a primary or a secondary alcohol.
 6. The process of claim 1, wherein compound (II) is methyl acetate.
 7. (canceled)
 8. The process of claim 1, wherein the catalyst is selected from catalysts of formula (V) and (VI):


9. The process of claim 8, wherein the catalyst is of formula (V).
 10. The process of claim 9, wherein compound (II) is selected from: methyl acetate, n-propyl acetate, i-propyl acetate, n-butyl acetate, i-butyl acetate, and glyceryl triacetate.
 11. The process of claim 9, wherein compound (II) is methyl acetate.
 12. The process of claim 9, wherein the reaction is performed in the presence of a base.
 13. The process of claim 12, wherein the base is NaBH₄.
 14. The process of claim 13, wherein compound (II) is selected from: methyl acetate, n-propyl acetate, i-propyl acetate, n-butyl acetate, i-butyl acetate, and glyceryl triacetate.
 15. The process of claim 13, wherein compound (II) is methyl acetate.
 16. The process of claim 8, wherein the catalyst is of formula (VI).
 17. The process of claim 16, wherein compound (II) is selected from: methyl acetate, n-propyl acetate, i-propyl acetate, n-butyl acetate, i-butyl acetate, and glyceryl triacetate.
 18. The process of claim 16, wherein compound (II) is methyl acetate.
 19. The process of claim 1, wherein the reaction is performed under neat conditions without the use of a solvent.
 20. The process of claim 1, wherein the reaction is performed in the presence of a solvent selected from THF, methanol, d₈-THF, and d₄-methanol.
 21. The process of claim 1, wherein the reaction is performed with a D₂ pressure of 0.1 to 20 MPa and a temperature of 25 to 125 ° C.
 22. The process of claim 1, wherein the reaction is performed at a temperature of 70 to 90° C.
 23. The process of claim 1, wherein the abundance of D in R⁴ and R⁵ is at least 90%.
 24. The process of claim 1, wherein the abundance of D in R⁴ and R⁵ is at least 90% and the abundance of D in R¹-R³ is at most 5%.
 25. The process of claim 1, wherein the abundance of D in R⁴ and R⁵ is at least 95% and the abundance of D in R¹-R³ is at most 1%.
 26. The process of claim 1, wherein the abundance of D in R⁴ and R⁵ is at least 99% and the abundance of D in R¹-R³ is at most 1%. 